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Communication | Regular issue | Vol 16, No. 8, 1981, pp.1271-1274
Published online, 1st January, 1970
DOI: 10.3987/R-1981-08-1271
Synthesis of Thieno[3,2-c]- and Thieno[2,3-c]pyrid-3-ones

Kyosuke Satake,* Toshiyuki Imai, Masaru Kimura, and Shiro Morosawa

*Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 Tsushima-naka, Okayama 700-8530, Japan

Abstract

The Friedel-Crafts cyclization of N-(3-thenyl)- and N-(2-thenyl)-glycine derivatives is described. The method leads to an alternative synthesis of 1,2,3,4-tetrahydro-N-[(2-chlorophenyl)methyl]thieno[3,2-c]pyridine(ticlopidine)(6d).