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Communication | Regular issue | Vol 16, No. 6, 1981, pp.951-954
Published online, 1st January, 1970
DOI: 10.3987/R-1981-06-0951
An Alternative Synthesis of (S)-(+)-γ-Hydroxymethyl-γ-butyrolactone from (D)-(+)-Mannitol

Seiichi Takano,* Emiko Goto, Michiyasu Hirama, and Kunio Ogasawara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

(S)-(+)-γ-Hydroxymethyl-γ-butyrolactone (6), which has been obtained from (S)-glutamic acid, is synthesized alternatively starting from (D)-(+)-mannitol (1).