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Communication | Regular issue | Vol 16, No. 6, 1981, pp.901-904
Published online, 1st January, 1970
DOI: 10.3987/R-1981-06-0901
The Absolute Configuration of (+)-Thalictricavine

Kinuko Iwasa and Mark Cushman*

*Department of Medicinal Chemistry and Molecular Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 1333 Robert E. Heine Pharmacy Building, West Lafayette IN 47907, Indiana 47907, U.S.A.


(+)-Thalictricavine (7) and (+)-canadine (1) have been synthesized from an optically resolved (+)-13-carboxy-7,8,13,14-tetrahydro-8-oxoprotoberberine 15. This establishes the absolute configuration of (+)-thalictricavine (7) as 13S, 14R.