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Report | Regular issue | Vol 16, No. 5, 1981, pp.795-798
Published online, 1st January, 1970
DOI: 10.3987/R-1981-05-0795
Synthesis of 1-Aryl-3-pyrrolin-2-one Derivatives

Katsumi Tabei,* Hideharu Ito, and Toyozo Takada

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

1-Aryl-3-pyrrolin-2-one derivatives (6a-e) were obtained from the corresponding γ-bromoacetoacetanilide derivatives (1a-e) in the overall yields of 31 - 48% through the reduction of the β-carbonyl group, acetylation of the hydroxyl group, and subsequent cyclization and elimination to the 3-pyrrolin-2-one structure.