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Communication | Regular issue | Vol 16, No. 5, 1981, pp.751-754
Published online, 1st January, 1970
DOI: 10.3987/R-1981-05-0751
Transformation of 5-(2-Nitrophenyl)-2-furylcarbamate into 4-Hydroxy-2-quinolinecarboxamide 1-Oxide

Kenichi Yakushijin, Rika Suzuki, Tomoko Tohshima, and Hiroshi Furukawa*

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan

Abstract

5-(2-Nitrophenyl)-2-furylcarbamates 1a-d are spontaneously cyclized to 4-hydroxy-2-quinolinecarboxamide 1-oxides 2a-d in benzene at room temperature by intramolecular reaction. This reaction provides a new synthetic route to kynurenic acid derivatives.