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Communication | Regular issue | Vol 16, No. 2, 1981, pp.215-220
Published online, 1st January, 1970
DOI: 10.3987/R-1981-02-0215
A General Synthesis of 7,9-Dialkyladeninium Salts

Tozo Fujii,* Tohru Saito, Teruyo Sakuma, Masako Minami, and Isao Inoue

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


Alkylations of N6-methoxy-9-methyladenine (I) and 9-alkyl-N6-benzyloxyadenines (II-IV) with MeI, EtI, and PhCH2Br in N,N-dimethylacetamide yielded the corresponding 7-alkylated derivatives (X, XIV-XVI), together with small amounts of the N6-alkylated isomers (V, VII-IX). Hydrogenolysis of the former compounds with hydrogen and Raney Ni produced 7,9-dialkyladenines (XI-XIII).