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Communication | Regular issue | Vol 16, No. 1, 1981, pp.31-34
Published online, 1st January, 1970
DOI: 10.3987/R-1981-01-0031
Syntheses of 2-Hydroxymethyl-4(3H)-quinazolinone and Its Analogs

Masayuki Ishikawa* and Yukuo Eguchi

*Tokyo Medical and Dental University, 2-3-10, Surugadai, Kanda, Chiyoda-ku 101-0062, Japan


The syntheses of 6-ethoxycarbonyl-2-hydroxymethyl-5,7-dimethyl-4(3H)-quinazolinone, 7-(or 6-)-ethoxycarbonyl-2,6,8-(or 2,5,7-)-trimethyl-3-phenyl-4(3H)-quinazolinone were described. The 3-phenyl-4(3H)-quinazolinone compounds were further converted to the corresponding 2-hydroxymethyl derivative. The starting compounds, 2-amino-4-ethoxycarbonyl-3,5-dimethylbenzoic acid and 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid were prepared by the Hofmann reaction of the corresponding phthalimide.