Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 16, No. 1, 1981, pp.25-30
Published online, 1st January, 1970
DOI: 10.3987/R-1981-01-0025
Syntheses of 4-Hydrocymethyl-1(2H)-phthalazinone and Its Analogs

Masayuki Ishikawa* and Yukuo Eguchi

*Tokyo Medical and Dental University, 2-3-10, Surugadai, Kanda, Chiyoda-ku 101-0062, Japan


4-Hydroxymethyl-1(2H)-phthalazinone (2) was preferably prepared by reduction of 4-ethoxycarbonyl-1(2H)-phthalazinone with NaBH4 in EtOH in good yield. The synthetic method was applicable for the preparation of 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone and its 2-phenyl derivative, where the regioselective reduction of the ester at the position 4 was possible, leaving the ester at the position 7 intact. The Grignard reaction of 4-ethoxycarbonyl-1(2H)-phthalazinone was also described.