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Communication | Regular issue | Vol 14, No. 10, 1980, pp.1437-1440
Published online, 1st January, 1970
DOI: 10.3987/R-1980-10-1437
An Efficient Reduction of Nitriles and Amides to the Corresposnding Amines with Tetra-N-butylammonium Borohydride in Dichloromethane

Takeshi Wakamatsu,* Harumi Inaki, Akemi Ogawa, Masako Watanabe, and Yoshio Ban

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan


The reduction of nitriles and amides to the corresponding amines with tetra-n-butylammonium borohydride in dichloromethane has been reported, in which the other functional groups such as ester, nitro, and halogen attached to the aromatic ring are not affected.