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Communication | Regular issue | Vol 14, No. 8, 1980, pp.1077-1080
Published online, 1st January, 1970
DOI: 10.3987/R-1980-08-1077
Synthetic Studies on Optically Active β-Lactams. Chiral Synthesis of Carbapenam Ring System Starting from L-Aspartic Acid

Nobuo Ikota, Hisanari Shibata, and Kenji Koga*

*Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan


Benzyl (3R,5R)-1-carba-2-oxopenam-3-carboxylate (12), a useful synthon for β-lactams having carbapenem ring system, was synthesized in optically pure state starting from L-aspartic acid.