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Review | Regular issue | Vol 14, No. 7, 1980, pp.985-1032
Published online, 1st January, 1970
DOI: 10.3987/R-1980-07-0985
Reactions at C-9 of Acridine Derivatives. Part XXV

Stanislaw Skonieczny*

*Laboratory of Chemistry and Biochemistry of Antitumour Compound, Institute of Organic and Food Chemistry and Technology, Techinical University of Gdansk, 80-952 Gdansk 6, Poland

Abstract

The kinetic data and mechanisms of the reactions occuring at the position 9 and/or 10 of the 9-substituted acridines have been reviewed. The mechanisms of hydrolysis and condensation reactions have been discussed and annelation effect considered where comparative data for the corresponding quinoline and pyridine derivatives were available. Some spactral and basicity data have been included to interpret the reaction mechanisms. Special attention has been payed to compounds of biological importance. The review falls into the following chapters according to the substituents undergoing substitution and/or types of the reactions being considered.