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Communication | Regular issue | Vol 14, No. 5, 1980, pp.625-630
Published online, 1st January, 1970
DOI: 10.3987/R-1980-05-0625
Minor Alkaloids in Commercial Samples of Colchicine

Maria A. Iorio, Anna Mazzeo-Farina, Guido Cavina, Luigi Boniforti, and Arnold Brossi*

*Section of Medicinal Chemistry, Laboratory of Bioorganic Chrmistry, NIDDK, National Institute of Health, Bethesda, MD 20892, U.S.A.

Abstract

Commercial samples of colchicine contain a total of about 5% of minor alkaloids as revealed by HPLC. Three minor alkaloids were isolated by preparative ThLC and identified by Mass Spectrometry to be N-formyldeacetylcolchicine, C-17-hydroxycolchicine and C-5 (or -6)-hydroxycolchicine.