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Review | Regular issue | Vol 14, No. 4, 1980, pp.505-529
Published online, 1st January, 1970
DOI: 10.3987/R-1980-04-0505
Synthesis of 2-Azabicyclo[3.3.1]nonanes

Joan Bosch* and Josep Bonjoch

*Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. de Joan XXIII, s/n, 08028 Barcelona, Spain


All methods for the synthesis of 2-azabicyclo[3.3.1]nonanes paying special attention to those which lead to functionalized systems are reviewed. This system, present in several alkaloids, is synthetically and theoretically interesting. The synthetic routes are classified according to the method used for the final cyclization to the morphan system.