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Report | Regular issue | Vol 14, No. 4, 1980, pp.471-476
Published online, 1st January, 1970
DOI: 10.3987/R-1980-04-0471
Characterization and Antimalarial Activity of Four Acetylated Pyrimethamines

Nancy Acton, Arnold Brossi,* David E. Davidson, Jr., and Thomas R. Sweeney

*Medical Chemistry Section, Laboratory of Chemistry, NIDDK, National Institute of Health, Bethesda, MD 20892, U.S.A.

Abstract

Acetylation of the antimalarial drug pyrimethamine afforded four different N-acetyl derivatives which were characterized. These Derivatives do not show sustained release activity but they are active antimalarials per se.