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Communication | Regular issue | Vol 14, No. 4, 1980, pp.449-451
Published online, 1st January, 1970
DOI: 10.3987/R-1980-04-0449
Novel Type of Analgesic — Synthesis and Analgesic Activity

Tetsuji Kametani,* Kazuo Kigasawa, Mineharu Hiiragi, Haruhide Ishimaru, Nagatoshi Wagatsuma, Toshitaka Kohagisawa, and Toshihisa Nakamura

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Two 4a-(3-hydroxyphenyl)decahydrocinnolines (7 and 9) have been synthesised from 2-(3-benzyloxyphenyl)-2-hydroxycarbonylmethylcyclohexanone (1), and both showed stronger analgesic activity than morphine.