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Communication | Regular issue | Vol 14, No. 4, 1980, pp.407-410
Published online, 1st January, 1970
DOI: 10.3987/R-1980-04-0407
A Novel Synthesis of Pyrido[2,3-d]pyrimidines by Reaction of Uracils with 6-Aminouracils via Pyrimidine-to-Pyridine Transformation

Kosaku Hirota, Yukio Kitade, and Shigeo Senda*

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


Reaction of 1,3-dimethyluracils with 1,3-dialkyl-6-aminouracils in basic media caused the pyrimidine-to-pyridine transformation to afford new pyrido[2,3-d]pyrimidine derivatives. A plausible mechanism for the ring transformation is offered.