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Communication | Regular issue | Vol 14, No. 4, 1980, pp.393-396
Published online, 1st January, 1970
DOI: 10.3987/R-1980-04-0393
Convenient Method for the Preparation of 2-Phenacylpyridines

Takeo Konakahara* and Yukio Takagi

*Department of Industrial Chemistry, Faculty of Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278-8510, Japan


2-Phenacylpyridines (3) were prepared from 2-(trimethylsilylmethyl)pyridine (1) and p-substituted benzonitriles (2) (X = H, Cl, CH3, OCH3) in high yields (70 ~ 99%) under a mild condition (LDA/THF, -75°C) . The method was compared with a reaction of α-picoline with (2) under the same condition. The keto-enol tautomerism of (3) were also discussed by means of the nmr spectra.