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Report | Regular issue | Vol 14, No. 2, 1980, pp.197-200
Published online, 1st January, 1970
DOI: 10.3987/R-1980-02-0197
Hydrolytic Ring Cleavage of Thiadiazolo[3,2-a]pyrimidinones

Tadakazu Tsuji* and Yoshimi Otsuka

*Department of Chemical and Biological Sciences, Faculty of Science, Japan Women’s University, 2-8-1 Mejirodai, Bunkyoku, Tokyo 112-0015, Japan


The alkali and acid hydrolysis of 2-substituted 7-methyl-5H-thiadiazolo[3,2-a]pyrimidin-5-ones gave 3-amino-6-methyluracil, 3-amino-6-methyl-2-thiouracil and 2-amino-1,3,4-thiadiazole derivatives according to the kind of substituents. While, the treatment of 7-methyl-5H-thiadiazolopyrimidin-5-one with methanolic hydrochloric acid gave 6-methyl-2-thiouracil.