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Report | Regular issue | Vol 12, No. 12, 1979, pp.1571-1574
Published online, 1st January, 1970
DOI: 10.3987/R-1979-12-1571
An Efficient Method for Synthesis of 1,1-Diarylhydrazines as an Intermediate for Indole Synthesis

Yasuoki Murakami* and Yuusaku Yokoyama

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan


The Hofmann reaction of 1,1-diarylureas (2) to afford the corresponding hydrazines (3) is described.
Diarylamines (1) were converted to 1,1-diarylureas (2) with sodium cyanate and trifluoroacetic acid, or chlorosulfonyl isocyanate. The Hofmann reaction of 2 with alkaline sodium hypochlorite in ethanol successfully gave the corresponding hydrazines (3) in good yields. This method is especially effective for the preparation of easily reducible 1,1-diarylhydrazine derivatives.