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Communication | Regular issue | Vol 12, No. 11, 1979, pp.1413-1416
Published online, 1st January, 1970
DOI: 10.3987/R-1979-11-1413
Bis-(Tetrahydroxy-dibenz[b,g]indolizine) by Air Oxidation of Tetrahydropapaveroline

Ching-Pong Mak and Arnold Brossi*

*Section of Medicinal Chemistry, Laboratory of Bioorganic Chrmistry, NIDDK, National Institute of Health, Bethesda, MD 20892, U.S.A.


THP was oxidized in aqueous alkaline milieu into a mixture of compounds. Two of them were dihydrodibenzoindolizines, isolated as their O-acetates. One was identical with a known monomer, the second proved to be a dimer.