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Communication | Regular issue | Vol 12, No. 11, 1979, pp.1407-1408
Published online, 1st January, 1970
DOI: 10.3987/R-1979-11-1407
Novel Ring Transformation of a 4H-Pyrido[1,2-a]pyrimidine into a 1,8-Naphthyridine

István Hermecz* and Zoltán Mészáros

*CHINOIN Pharmaceutical and Chemical Works Ltd., P. O. Box 110, H-1325 Budapest, Hungary

Abstract

Ethyl 4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylates (1) can be converted into ethyl 4-oxo-1,4,5,6,7,8-hexahydro-1,8-naphthyridine-3-carboxylates (2) under basic conditions.