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Communication | Regular issue | Vol 12, No. 11, 1979, pp.1391-1396
Published online, 1st January, 1970
DOI: 10.3987/R-1979-11-1391
A Study of the Binding of Methylene Blue, Thionin, Azure A, Azure B, and Azure C to DNA

Scott A. Burton and Raymond N. Castle*

*Department of Chemistry, Brigham Young University, Provo, UT 84602, U.S.A.

Abstract

Methylene Blue, Thionin, Azure A, Azure B, and Azure C were found to bind strongly to DNA probably via intercalation. Binding affinity is the result of several factors including π moment along the long axis and dipoIe-dipoIe coupling both constrained by steric effects.