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Review | Regular issue | Vol 12, No. 10, 1979, pp.1343-1368
Published online, 1st January, 1970
DOI: 10.3987/R-1979-10-1343
Synthetic Reactions Using Isoxazole Compounds

Choji Kashima*

*Department of Chemistry, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba-shi, Ibaraki, 305-8571, Japan


The activation of C-5 methyl group of 3,5-dimethylisoxazoles is discussed by MINDO/2 calculation and H-D exchange reaction. The regioselective substitution reaction of 5-methylisoxazoles with electrophiles such as alkyl halides, carbon dioxide, carbonyl compounds, Schiff bases, nitriles, nitrites and nitroso compounds is reviewed. Also the conversions of resulting isoxazole derivatives to β-diketones, enones and some heterocyclic compounds are reviewed.