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Communication | Regular issue | Vol 12, No. 10, 1979, pp.1323-1326
Published online, 1st January, 1970
DOI: 10.3987/R-1979-10-1323
Synthesis and Metabolism of 5-Alkylpyrimidine-2-carboxylic Acids

Hiroshi Yamanaka,* Michinao Mizugaki, Mataichi Sagi, Kiyoto Edo, Hiroshi Miyazaki, Hideki Takayama, and Yukiko Minatoagwa

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

The metabolism of 5-propylpyrimidine-2-carboxylic acid, an azalogue of fusaric acid, has been investigated. The chain-elongated metabolites in the carboxyl group at the 2-position on the ring were identified in rat urine. The synthesis of the substrate and its main metabolite is also described.