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Communication | Regular issue | Vol 12, No. 10, 1979, pp.1315-1318
Published online, 1st January, 1970
DOI: 10.3987/R-1979-10-1315
Syntheses of Some Dithioketene Acetal Azetidinone Derivatives

Masayuki Shibuya* and Seiju Kubota

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi 1, Tokushima 770-8505, Japan

Abstract

Dithioketene acetal azetidinone derivatives (3)-(8) were prepared by the base induced reaction of 4-acetoxyazetidin-2-one (1) with β-hydroxydithiocinnamic ester and its analogues. The E and Z isomers of the products were separated and their configurations were determined in NOE experiments. Both isomers of compounds (3)-(7) showed moderate synergistical activity with penicillins against some resistant strains of bacteria.