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Communication | Regular issue | Vol 12, No. 9, 1979, pp.1183-1187
Published online, 1st January, 1970
DOI: 10.3987/R-1979-09-1183
The Facile Synthsis of an Important Key Intermediate for the Synthesis of (±)-8S*-Thienamycin — A Formal Total Synthesis of (±)-8S*-Thienamycin

Tetsuji Kametani,* Shyh-Pyng Huang, and Masataka Ihara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


8S*-Isomer of the potent antibiotic thienamycin (1) was formally synthesized in short steps via trans-4-methoxycarbonyl-3-(2’,2’-dimethoxyethyl)-5-methylisoxazoline (5).