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Communication | Regular issue | Vol 12, No. 6, 1979, pp.783-786
Published online, 1st January, 1970
DOI: 10.3987/R-1979-06-0783
Structure of Ephedradine B, a Hypotensive Pronciple of Ephedra Roots

Mitsuru Tamada, Katsuya Endo, and Hiroshi Hikino*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

From the crude drug “mao-kon”, the roots of Ephedra plants, a novel macrocyclic spermine alkaloid ephedradine B showing the hypotensive activity has been isolated whose stereostructure has been elucidated as represented by formula I on the basis of chemical and physical evidence.