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Communication | Regular issue | Vol 12, No. 6, 1979, pp.741-744
Published online, 1st January, 1970
DOI: 10.3987/R-1979-06-0741
Synthetic Studies on β-Lactam Antibiotics. VI. Synthesis of 7H-azeto[1,2-a]thieno[2,3-c]pyridine Derivatives

Tetsuji Kametani,* Keiichiro Fukumoto, Kazuo Kigasawa, Mineharu Hiiragi, Kikuo Wakisaka, Keiso Tanigawa, and Hideo Sugi

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Methyl 4,5-dihydrothieno[2,3-c]pyridine-5-carboxylate (4) was converted into several 8-substituted 4,5,8,8a-tetrahydro-7-oxo-7H-azeto[1,2-a]thieno[2,3-c]pyridine-7-carboxylates (7 ~ 10) by reaction with phthalimidoacetyl chloride and triethylamine, followed by hydrolysis and acylation.