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Communication | Regular issue | Vol 12, No. 4, 1979, pp.511-514
Published online, 1st January, 1970
DOI: 10.3987/R-1979-04-0511
Synthesis of the 8H-Isoquino[2,1-b][2]benzazocine System via 1,3-Dipolar Cycloaddition of 8-Methoxyberberinephenolbetaine

Miyoji Hanaoka,* Akimori Wada, Shingo Yasuda, Chisato Mukai, and Takeshi Imanishi

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


Reaction of 8-methoxyberberinephenolbetaine with various acetylenic compounds afforded the 1,3-dipolar cycloadducts, which were heated subsequently in ethanol to provide the 8H-isoquino[2,1-b][2]benzazocines in excellent yields.