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Communication | Regular issue | Vol 12, No. 4, 1979, pp.485-488
Published online, 1st January, 1970
DOI: 10.3987/R-1979-04-0485
Synthesis and Reactions of 3-Methylthioisotyhiazolo[3,4-d]pyrimidine-4,6(5H,7H)-diones

Hiroto Okuda, Yoshinori Tominaga, Yoshiro Matsuda, and Goro Kobayashi*

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

3-Methylthioisothiazolo[3,4-d]pyrimidine-4,6-(5H,7H)-diones (IIIa, b) were synthesized by treatment of methyl 6-aminouracil-5-dithiocarboxylates, which were prepared by the reaction of 6-aminouracil with carbon disulfide and dimethyl sulfate in the presence of alkali, with iodine in dimethyl sulfoxide in good yields. The reaction of IIIa, b with amines, amides, and active methylene compounds gave the corresponding substituted products of methylthio group in III in good yields.