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Communication | Regular issue | Vol 12, No. 2, 1979, pp.247-251
Published online, 1st January, 1970
DOI: 10.3987/R-1979-02-0247
Biotransformation of Some 2-Methylpapaverinium Derivatives with Rat Liver Enzymes in Vitro

Dana Walterová,* Alice Nemecková, Vladimír Preininger, Vilím Simánek, and Ladislav Dolejs

*Institute of Medical Chemistry, Palacky University, 3, Hnevotínská, 775 15 Olomouc, Czech Republic


2-Methyl-3,4-dihydropapaverinium derivatives (1-3) and 2-methylpapaverinium chloride (4) have been converted into the corresponding isoquinolones and carbonyl compounds by incubation with rat liver preparations. The role of pseudobase formation in this biotransformation is discussed.