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■ Biotransformation of Some 2-Methylpapaverinium Derivatives with Rat Liver Enzymes in Vitro

Dana Walterová,* Alice Nemecková, Vladimír Preininger, Vilím Simánek, and Ladislav Dolejs

*Institute of Medical Chemistry, Palacky University, 3, Hnevotínská, 775 15 Olomouc, Czech Republic

Abstract

2-Methyl-3,4-dihydropapaverinium derivatives (1-3) and 2-methylpapaverinium chloride (4) have been converted into the corresponding isoquinolones and carbonyl compounds by incubation with rat liver preparations. The role of pseudobase formation in this biotransformation is discussed.