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Communication | Regular issue | Vol 12, No. 2, 1979, pp.239-242
Published online, 1st January, 1970
DOI: 10.3987/R-1979-02-0239
A Synthesis of 3-Hydroxyiminoacryl-4-quinazolines and Transformation into 1,2,4-Oxadiazoles

Katsuhiko Nagahara* and Atsushi Takada

*School of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan


Treatment of N-hydroxyiminobenzyl-2-aminobenzamides (I) with ortho esters afforded the corresponding 2-alkyl-3-hydroxyiminoacyl-4-quinazolones (II) and 3,5-diaryl-1,2,4-oxadiazoles (III), respectively. Furthermore, treatment of II with ethanolic hydrochloric acid caused the ring transformation to give the corresponding III.