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Communication | Regular issue | Vol 12, No. 1, 1979, pp.29-35
Published online, 1st January, 1970
DOI: 10.3987/R-1979-01-0029
Synthesis of 9-Deoxy-9-ethoxycarbonyl-9-azaprostaglandin E2 Ethyl Ester

Gerard P. Rozing, Johannes Kip, Willem Edam, Henk de Koning,* and Henderikus O. Huisman

*Laboratory of Organic Chemistry, University of Amsterdam, Nieuwe Achtergracht 129,1018 WS Amsterdam, The Netherlands

Abstract

9-Deoxy-9-ethoxycarbonyl-9-azaprostaglandin E2 ethyl ester 1 and its C15-epimer 2 were synthesized from the readily available protected triol 3 by selective deprotection of successive hydroxyl functions and subsequent side chain construction.