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Communication | Regular issue | Vol 9, No. 10, 1978, pp.1391-1395
Published online, 1st January, 1970
DOI: 10.3987/R-1978-10-1391
Studies on the Biosynthesis of Bisindole Alkaloids. The Final Stages in Biosynthesis of Vinblastine, Leurosine and Catharine

Kenneth L. Stuart, James P. Kutney,* Toshio Honda, and Brian R. Worth

*Department of Chemisry, University of British Columbia, Vancouver 8, V5T 1W5, Canada

Abstract

Radiolabelling experiments have demonstrated the incorporation by Catharanthus roseus cell free extracts of 3’,4’-dehydrovinblastine into vinblastine, leurosine and catharine. The enzyme catalysed formation of catharine from leurosine indicated that the former is not an artefact.