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Communication | Regular issue | Vol 9, No. 10, 1978, pp.1387-1390
Published online, 1st January, 1970
DOI: 10.3987/R-1978-10-1387
New Synthesis of 2-Aryl-1,2,4-triazine-3,5(2H,4H)-diones (1-Aryl-6-azauracils)

Fumio Yoneda,* Masatsugu Higuchi, and Yoshihiro Nitta

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan

Abstract

Treatment of 6-amino-5-arylazo-l,3-dimethyluracils with urea gave the respective 6-aryl-1,3-dimethyl-6,7-dihydro- 6-azalumazine-7(6H)-ones, which were hydrolyzed with alkali to afford 2-aryl-1,2,4-triazine-3,5(2H,4H)-dione-6-carboxylic acids (1-aryl-6-azauracil-5-carboxylic acids). Thermal decarboxylation of these carboxylic acids gave the corresponding 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones (1-aryl-6-azauracils).