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Communication | Regular issue | Vol 9, No. 10, 1978, pp.1367-1373
Published online, 1st January, 1970
DOI: 10.3987/R-1978-10-1367
Oxidative Cyclization of 2-Unsaturated 1,4-Dioximes

Akio Ohsawa, Heihachiro Arai, and Hiroshi Igeta*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan


The major product of the oxidation of 1,4-diphenyl-2-butene-1,4-dioxime (4c) with phenyliodoso bis trifluoroacetate (PITFA) was 3,6-diphenyl-dihydroisoxazoloisoxazole (2c) which had been incorrectly assigned to the 3,6-diphenylpyridazine dioxide (1c) by other authors. Lead tetraacetate was found to be more applicable reagent than PITFA for the preparation of dioxides(1) from 2-unsaturated 1,4-dioximes.