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Communication | Regular issue | Vol 9, No. 9, 1978, pp.1197-1206
Published online, 1st January, 1970
DOI: 10.3987/R-1978-09-1197
Synthesis of 3-Isoquinolines

Hiroshi Fukumi* and Hideshi Kurihara

*Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

Abstract

Treatment of N-benzyl-diethoxyacetamides and N-alkyl-N-benzyl-diethoxyacetamides with sulfuric acid afforded the corresponding 3-isoquinolinols and 2-alkyl-3-isoquinolones, respectively. This reaction is regarded as a kind of Pomeranz-Fritsch synthesis.