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Review | Regular issue | Vol 9, No. 8, 1978, pp.1089-1119
Published online, 1st January, 1970
DOI: 10.3987/R-1978-08-1089
The Spiroindolenine Intermediate, a Review

Frank Ungemach and James M. Cook*

*Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, U.S.A.


The Pictet-Spengler reaction has been employed to prepare 1,2,3,4-tetrahydro-β-carbolines for many years and is presumed to go through the spiroindolenine intermediate (XIX). A review of the evidence for this mechanism is presented.