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Communication | Regular issue | Vol 9, No. 8, 1978, pp.1015-1022
Published online, 1st January, 1970
DOI: 10.3987/R-1978-08-1015
Studies on the Synthesis of Bisindole Alkaloids. XIV. Enzyme Catalysed Formation of Leurosine

Kenneth L. Stuart, James P. Kutney,* and Brian R. Worth

*Department of Chemisry, University of British Columbia, Vancouver 8, V5T 1W5, Canada


Enzyme catalysed oxidation of 3’,4’-dehydrovinblastine using either horseradish peroxidase or cell free extracts from Catharanthus roseus plants provided leurosine, suggesting that the latter is in fact a natural product.