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Communication | Regular issue | Vol 9, No. 6, 1978, pp.727-730
Published online, 1st January, 1970
DOI: 10.3987/R-1978-06-0727
Studies on the Synthesis of 13-Methyltetrahydroprotoberberine Derivative

Hideo Iida,* Mamoru Narimiya, Nobuko Katoh, Hiroji Ina, and Toyohiko Kikuchi

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


4-Methylated isocarbostyril derivative (VII) was reduced with lithium aluminum hydride, followed by an acidic treatment to give the trans-13-methyltetrahydroprotoberberine (VIII).