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Communication | Regular issue | Vol 9, No. 4, 1978, pp.443-448
Published online, 1st January, 1970
DOI: 10.3987/R-1978-04-0443
Synthesis of Peptide Alkaloid, Amphibine-I and Related Compounds

Juno Koyama, Yukio Suzuta, Kaoru Kuriyama, Haruaki Yajima, Kaname Koyama, and Hiroshi Irie*

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan


Synthesis of amphibine-I (IA-a) and its diastereoisomeric compounds (IA-b), (IB-a), and (IB-b) was completed by condensation of four diastereoisomeric 1-(α-aminoethyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines (VA-a,b and VB-a,b) with benzyloxycarbonyl-L-valylglycine followed by removal of the protecting group.