Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 9, No. 4, 1978, pp.443-448
Published online, 1st January, 1970
DOI: 10.3987/R-1978-04-0443
Synthesis of Peptide Alkaloid, Amphibine-I and Related Compounds

Juno Koyama, Yukio Suzuta, Kaoru Kuriyama, Haruaki Yajima, Kaname Koyama, and Hiroshi Irie*

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

Synthesis of amphibine-I (IA-a) and its diastereoisomeric compounds (IA-b), (IB-a), and (IB-b) was completed by condensation of four diastereoisomeric 1-(α-aminoethyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines (VA-a,b and VB-a,b) with benzyloxycarbonyl-L-valylglycine followed by removal of the protecting group.