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Communication | Regular issue | Vol 9, No. 3, 1978, pp.271-274
Published online, 1st January, 1970
DOI: 10.3987/R-1978-03-0271
Coupling Reaction of Monosubstituted Acetylenes with Iodopyrimidines

Kiyoto Edo, Hiroshi Yamanaka,* and Takao Sakamoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


The pyrimidine derivatives containing an acetylenic side chain at the 2- or 4-position were synthesized by means of the reaction of alkyl(or phenyl)acetylenes with 2-iodo- or 4-iodopyrimidines in the presence of a palladium triphenylphosphine complex in yields ranging from 70 to 95 %. The reaction readily proceeded in both 2,4-diiodo- and 4,6-diiodopyrimidines to give the corresponding dialkynyl derivatives.