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Communication | Regular issue | Vol 6, No. 11, 1977, pp.1871-1876
Published online, 1st January, 1970
DOI: 10.3987/R-1977-11-1871
A New Synthesis of 3,4-Diaminothiophenes

Yoshinori Tominaga, Hiroshi Fujito, Yoshiro Matsuda, and Goro Kobayashi*

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan


3,4-Diaminothiophenes were synthesized by the cleavage of pyridine ring in 3-aminothien-4-yl-pyridinium iodides, which were prepared by the reaction of 1-cyanomethylpyridinium chloride with carbon disulfide and alkylating agents in the presence of alkali, followed by the base-catalyzed interamolecular cyclization.
The reaction of 3,4-diaminothiophenes with 1,2-dicarbonyl derivatives gave thieno[3,4-b]pyrazines in a good yield.