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Communication | Regular issue | Vol 6, No. 11, 1977, pp.1841-1845
Published online, 1st January, 1970
DOI: 10.3987/R-1977-11-1841
The Rections and Syntheses with Organometallic Compounds. VIII. The Total Synthesis of Sendaverine by Use of the Palladium Catalyzed Insertion of Carbon Monoxide

Miwako Mori, Katsumi Chiba, and Yoshio Ban*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan

Abstract

The alkaloid, sendaverine (3), which was isolated from Corydalis aurea Willd. was synthesized from the 2-bromophenethylamine derivative (10) as an extension of the synthetic method of benzolactams by palladium catalyzed insertion of carbon monoxide.