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Communication | Regular issue | Vol 6, No. 11, 1977, pp.1833-1839
Published online, 1st January, 1970
DOI: 10.3987/R-1977-11-1833
■ Cyclodextrin-Nitrophenol Systems Studied by Polarography

Tetsuo Osa,* Tomokazu Matsue, and Masamichi Fujihara

*Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, sendai 980-8578, Japan

Abstract

The effects of added α- and β-cyclodextrins on the half-wave potentials and the diffusion coefficients of o-, m-, and p-nitrophenols were examined, and a new polarographic method for determining the dissociation constants of cyclodextrin-substrate complexes was proposed. The dissociation constants of p-nitrophenol-cyclodextrin complexes obtained by polarographic method are in good agreement with those determined by spectrophotometric method. This polarographic method is applicable to many electroactive compound-cyclodextrin complexes whose dissociation constants can hardly be determined by spectrophotometric method.