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Communication | Regular issue | Vol 6, No. 11, 1977, pp.1817-1820
Published online, 1st January, 1970
DOI: 10.3987/R-1977-11-1817
A Facile Synthesis of Substituted Pyrimidines by Ring Transformation of 1,3-Oxazin-4-ones

Yutaka Yamamoto* and Yutaka Azuma

*Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Abstract

Treatment of 6-methyl-2-phenyl-4H-1,3-oxazin-4-one (1) and 2-benzyl-2-ethoxy-6-methyl-3,4-dihydro-2H-1,3-oxazin-4-one (2) with thioamides led to conversion into the corresponding 2,6-disubstituted 5-acetyl-4-hydroxypyrimidines 3a-e and 4a,b, respectively.