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Report | Regular issue | Vol 6, No. 8, 1977, pp.1179-1180
Published online, 1st January, 1970
DOI: 10.3987/R-1977-08-1179
A Sinthesis of Flavins by Nitrosative Cyclization of 6-(N-Alkylaminilino)uracils with N-Nitrosodimethylamine-Phosphorus Oxychloride Mixture

Fumio Yoneda,* Kazuo Shinozuka, Yoshiharu Sakuma, and Keitaro Senga

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan

Abstract

Treatment of 6-(N-alkylanilino)uracils with a mixture of N-nitrosodimethylamine (NDA) and phosphorus oxychloride gave directly the corresponding isoalloxazines (flavins).