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Communication | Regular issue | Vol 6, No. 7, 1977, pp.959-963
Published online, 1st January, 1970
DOI: 10.3987/R-1977-07-0959
A Simple Conversion of Norcoralyne into Phthalideisoquinoline

Jiro Imai and Yoshikazu Kondo*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

A new simple conversion of the berberine type alkaloid into the phthalideisoquinoline alkaloid was described by a sequence involving intramolecular rearrangement of the 8,13a-epidioxy intermediate B via the three-membered cyclic peroxide D, to 2’-carboxypapaveraldine which was reduced with NaBH4 to give the phthalideisoquinoline 5.