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Report | Regular issue | Vol 6, No. 5, 1977, pp.547-550
Published online, 1st January, 1970
DOI: 10.3987/R-1977-05-0547
Convenient Synthesis of Nicotinamide Derivatives

Takushi Kurihara* and Toshiko Uno

*Faculty of Pharmaceutical Science, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan


A one-step synthesis of 5-acetyl-4-ethoxycarbonyl-2-methylnicotinamide (IV) by the reaction of ethyl 3-ethoxymethylene-2,4-dioxovalerate (I) with β-aminocrotonamide (II) was described, and this was easily converted to nicotinamide derivatives (VI, VII, and VIII).