Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 6, No. 5, 1977, pp.535-540
Published online, 1st January, 1970
DOI: 10.3987/R-1977-05-0535
Studies on the Reactivity of Isoquinoline and Related Compounds. IV. Addition Reaction of Active Methylene Compounds with Isoquinline

Takayuki Shiraishi and Hiroshi Yamanaka*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


In connection with addition reaction of acetic anhydride to the isoquinoline nucleus, reaction of active methylene compounds with isoquinoline (I) in acetic anhydride was investigated. Thus, the N-acetyl-1,2-dihydroisoquinoline derivatives such as 1-acetonyl- (IV), 1-phenacyl-2-acetyl-1,2-dihydroisoquinoline (X), diethyl 2-acetyl-1,2-dihydro-1-isoquinolylmalonate (XII), and α-(2-acetyl-1,2-dihydro-1-isoquinolyl)phenylacetic acid (XIII) were obtained.