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Communication | Regular issue | Vol 6, No. 5, 1977, pp.535-540
Published online, 1st January, 1970
DOI: 10.3987/R-1977-05-0535
Studies on the Reactivity of Isoquinoline and Related Compounds. IV. Addition Reaction of Active Methylene Compounds with Isoquinline

Takayuki Shiraishi and Hiroshi Yamanaka*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

In connection with addition reaction of acetic anhydride to the isoquinoline nucleus, reaction of active methylene compounds with isoquinoline (I) in acetic anhydride was investigated. Thus, the N-acetyl-1,2-dihydroisoquinoline derivatives such as 1-acetonyl- (IV), 1-phenacyl-2-acetyl-1,2-dihydroisoquinoline (X), diethyl 2-acetyl-1,2-dihydro-1-isoquinolylmalonate (XII), and α-(2-acetyl-1,2-dihydro-1-isoquinolyl)phenylacetic acid (XIII) were obtained.